Positive Signs - Delusions

Central Executive

Top-Down Shift

Top-Down Hierarchal Shift as part of an hierarchal imbalance constrains and biases upcoming experience creating false ideation (Delusions) about transpiring  Experience. These alteration involve millisecond-range neuronal and cognitive activity             

IMAGING

Search for increased connectivity within efferent pathways from frontal regions to peripheral locations. Dynamic causal modeling will show top-down shift in hierarchal networks manifested both in correlation matrixes and graph analysis.    

NEUROMODULATION

Aim to reduce prefrontal activation using inhibitory modulation. Increase bottom-up connectivity by stimulating unimodal multimodal activity in comparison to trans modal higher-level connectivity  

Positive Signs - Delusions

Central Executive

Top-Down Shift

Central Executive

Top-Down Hierarchal Shift as part of an hierarchal imbalance constrains and biases upcoming experience creating false ideation (Delusions) about transpiring Experience. These alteration involve millisecond-range neuronal and cognitive activity.

IMAGING

Expect reduction in parameters of correlation matrixes and reduced weights on graph analysis edges. Expect reduced degrees for Hubs spread out globally in the brain. Identify disturbance of small-world dynamics toward random unstable measurements    

NEUROMODULATION

Aim to reduce prefrontal activation using inhibitory modulation. Increase bottom-up connectivity by stimulating unimodal multimodal activity in comparison to trans modal higher-level connectivity  

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