Maturation and development of the Default-Mode-Network is a life-long process of interacting with the environmental experiences. It is an experience –dependent plasticity process. Any disturbance to this process, including unstable environments, hampers Default-Mode-Network maturation. Immature mismatching biased internal Representations cause non-adaptive faulty psychosocial functionality (personality disorders), deoptimization(mood alterations) and instability (anxiety) and possible fragmentation with psychotic vulnerability
Changes are expected in timescales of years. Most notably the network maturation should be measured in terms of small- worldliness as it is expected that the maturing brain assumes small-world organization as it matures. Alife-trajectory of mature brains should be compared with trajectories of immature personality-disordered brains and a ‘bias measure’ would probably detect and diagnose this disorder
Massive global increase of brain plasticity is beneficial for a maturing brain and for the evolution of small worldliness. However, maturation is heavily depended on ‘Experience Dependent Plasticity thus experience control should be added via real-time experiences (including psychotherapy) or artificially controlled Virtual Reality experiences.