Immature rudimental biased Default Mode Network with internal configurations that are non-adaptive and biased in respect to occurring conditions may generate Connectom spread instability with increased frustration on constraints thus perturbing the networks creating instability that is expressed by anxious feeling as an emergent property
Lifelong assessments of Default Mode Network graphs should be collected to identify small-world network disturbances and biases. In addition network instability of constraint frustration is expected to have anxiety as emergence property. Experience-dependent plasticity interventions together with increased plasticity to stabilize constraints is warranted.
Traditionally for anxiety Serotonin Specific Reuptake Inhibitors (SSRI’s) and Anxiolytics are administrated induction of neuronal plasticity is achieved with SSRI’s theoretically consider alternative (or enhancing) neuronal-plasticity induction using prefrontal transcranial Magnetic Stimulation (TMS) transcranial or Direct Current Stimulation tDCS. Consider adding Virtual Reality (VR) calming meditative experience-plasticity-inducing environments. For personality disorders there is an important value for plasticity induction combination with psychotherapy (which is actually Experience-dependent-plasticity induction). Additionally, consider personalized Virtual-Reality (VR) psychotherapy. Use any intervention that will enhance Small World Network maturation.