During De-optimization dynamics inducing maladaptation mismatch and increase free energy between computing occurrences in the executive network and their internal representations of the Default-mode network, during such perturbation instability of the network Connectom can spread constraint-frustration among network units. Emerging as spread instability and anxious feeling
Imaging will involve the Executive Network and Default Mode Network and should be assessed over time window of months assessing free-energy delta distance (Humming distance like measure) which is expected to increase and also reflect destabilization. Treatment will need to increase plasticity. More spines dendrite and neurons will enable increased brain plasticity with free energy reducing effect
Traditionally Serotonin Specific Reuptake Inhibitors (SSRI’s) are administrated also theoretically consider alternative (enhancing) neuronal-plasticity induction using cortical transcranial Magnetic Stimulation (TMS) transcranial Direct Current Stimulation tDCS, transcranial random Direct Current Stimulation trDCS. For the anxiety dimension consider adding Virtual Reality (VR) calming meditative experience-plasticity-inducing environments. Additionally, consider Cognitive Behavioural Therapy like (CBT-like) personalized Virtual-Reality (VR) interventions. Use any intervention that will increase plasticity and reduce free energy.