In the process of disconnection and fragmentation of the connectome it is possible that Hyper-optimization dynamics occur with hyper matching (i.e., reduced Free Energy) between the Executive Network and Default Mode Network. Part of the hyper-optimization dynamics can generate Top-down Hierarchical bias where higher level ideation biases in coming actual experience, by a faulty error correction hierarchical dynamics
Imaging will involve reduced correlation matrix entries, and connectivity graphs will show disturbance of Small-World Network with reduced clustering coefficients. Also hyper-optimization dynamic scan occur. Treatment will have to reconnect and stabilize connectivity-optimization via intervention in the hubs that increase connectivity dynamics.
Traditionally antipsychotics are administrated theoretically also consider modulating global integration using Dorsolateral Prefrontal Hub-related transcranial Alternating Current Stimulation (tACS) to reconnect global network (increase Gamma synchronization). For delusions consider modulating cortical hierarchical balance using tACS to desynchronize unimodal and transmodal cortices to reduce top-down biased effects (e.g., reduce Gamma synchronization between parietal and prefrontal cortices). Consider administering opposing Delusions-related specific Virtual-Reality environments, and for Manic manifestations consider adding Virtual Reality (VR) calming meditative environments.