In the process of disconnection and fragmentation of the connectome it is possible that Hyper-optimization dynamics occur with hyper matching  (i.e., reduced Free Energy) between the Executive Network and Default Mode Network.  
Imaging will involve reduced correlation matrix entries, and connectivity graphs will show disturbance of Small-World Network with reduced clustering coefficients. Also hyper-optimization dynamics can occur.   Treatment will have to reconnect and stabilize connectivity-optimization via intervention in the hubs that increase connectivity dynamics.
Traditionally antipsychotics are administrated theoretically also consider modulating global integration using Dorsolateral Prefrontal Hub-related transcranial Alternating Current Stimulation (tACS) to reconnect global network (increase Gamma synchronization). For Mania Consider adding Virtual Reality (VR) calming meditative environments.