DESCRIPTION
In the process of disconnection and fragmentation of the connectome it is possible that Hyper-optimization dynamics occur with hyper matching  (i.e., reduced Free Energy) between the Executive Network and Default Mode Network.  
-----------------IMAGING------------------
Imaging will involve reduced correlation matrix entries, and connectivity graphs will show disturbance of Small-World Network with reduced clustering coefficients. Also hyper-optimization dynamics can occur.   Treatment will have to reconnect and stabilize connectivity-optimization via intervention in the hubs that increase connectivity dynamics.
-----------------TREATMENT---------------
Traditionally antipsychotics are administrated theoretically also consider modulating global integration using Dorsolateral Prefrontal Hub-related transcranial Alternating Current Stimulation (tACS) to reconnect global network (increase Gamma synchronization). For Mania Consider adding Virtual Reality (VR) calming meditative environments.     
Description
Treatment