In the process of disconnection and fragmentation of the connectome it is possible that  Top-down Hierarchical bias is formed where higher level ideation biases incoming actual experience, by a faulty error-correction hierarchical dynamics    
Imaging correlation matrices and graph analysis will show spread of reduced correlations, but  higher correlation between dorsolateral prefrontal cortex(dlPFC) and peripheral cortical networks Treatment is aimed at interneuronal dlPFC modulating  activity that can increase hierarchical organization back to its proper function.
Traditionally antipsychotics are administrated theoretically also consider modulating global integration using Dorsolateral Prefrontal Hub-related transcranial Alternating Current Stimulation (tACS) to reconnect global network (increase Gamma synchronization).  For Delusions consider modulating cortical hierarchical balance using tACS to desynchronize unimodal and transmodal cortices to reduce top-down biased effects (e.g., reduce Gamma synchronization between parietal and prefrontal cortices).  Consider administering opposing Delusions-related specific Virtual-Reality environments.