During hierarchical Bottom-up insufficiency. Higher-level brain organizations are fragmented and lost, thus higher levels of brain organization for volition is destroyed It is possible that unimodal cortical processor becomes disconnected from the global network of active executive computation, the Central Executive network as well as from external input
dorsolateral prefrontal cortical (dlPFC)organization is hampered or even lost altogether. Connections from peripheral unimodal cortical regions are weak. Perceptual sub-network can remain hyperactive, this will show up on correlation matrixes and graph analysis. Treatment is aimed at inter neuronal dlPFC modulating activity that can increase hierarchical organization back to its proper function.
Traditionally antipsychotics are administrated theoretically consider modulating cortical hierarchical balance using transcranial Alternating Current Stimulation (tACS) to resynchronize unimodal and transmodal cortices and rebuilt hierarchal bottom-up (e.g., increase Gamma) synchronization between parietal and prefrontal cortices). For hallucinations consider locally focused cortical low-frequency suppressive TMS. Additionally consider administering Hallucinations-related specific Virtual-Reality environments (personalized controlled talking Avatars). Combine that with prefrontal-cortical cognitive exercise for frontal cortical experience-plasticity-inducing environments (i.e., activating the plasticity of prefrontal cortex).