In a disconnected global Connectom with different cortical systems acting statistically independent from each other it is just natural that specific subsystems processing perceptual modalities will disconnect from the Connectom and act independently also from incoming perceptual stimuli. Since hierarchal top-down and bottom-up processes are also related to connectivity, the hierarchical connectivity, thus top-down biase of incoming information can occur resulting in Delusions
Imaging will involve reduced correlation matrix entries, and connectivity graphs will show disturbance of Small-World Network with reduced clustering coefficients. Unimodal perceptual subsystems will split off acting independently(Hallucinations) and dorsolateral prefrontal cortical (dlPFC)connections to peripheral unimodal cortical regions are stronger then incoming signal from periphery.This will show up on correlation matrixes and graph analysis. Treatment is aimed at interneuronal dlPFC modulating activity.
Traditionally antipsychotics are administrated theoretically also consider locally focused cortical low-frequency suppressive TMS. For hallucinations and loos-associations consider modulating global integration using Dorsolateral Prefrontal Hub-related transcranial Alternating Current Stimulation (tACS) to reconnect global network (increase Gamma synchronization). For Delusions consider modulating cortical hierarchical balance using tACS to desynchronize unimodal and transmodal cortices to reduce top-down biased effects (e.g., reduce Gamma synchronization between parietal and prefrontal cortices). Consider administering opposing Delusions-related specific Virtual-Reality environments.