Specific subsystems processing perceptual modalities disconnect from the Connectom and act independently also from incoming perceptual stimuli. Since hierarchial top-down and bottom-up processes are also related to connectivity,the hierarchical connectivity, thus top-down bias of incoming information can occur resulting in Delusions
Imaging will involve reduced correlation matrix entries, connection matrix toward Unimodal perceptual subsystems will be reduced (Hallucinations) and dorsolateral prefrontal cortical (dlPFC)connections to peripheral unimodal cortical regions are stronger then incoming signal from periphery.This will show up on correlation matrixes and graph analysis. Treatment is aimed at inter neuronal dlPFC modulating activity.
Traditionally antipsychotics are administrated theoretically also consider locally focused cortical low-frequency suppressive TMS. For modulating global integration consider Dorsolateral Prefrontal Hub-related transcranial Alternating Current Stimulation (tACS) to modulate global network (Gamma activity). Consider administering Hallucinations-related specific Virtual-Reality environments (personalized controlled talking Avatars). For Delusions consider modulating cortical hierarchical balance using tACS to desynchronize unimodal and transmodal cortices to reduce top-down biased effects (e.g., reduce Gamma synchronization between parietal and prefrontal cortices). Consider administering opposing Delusions-related specific Virtual-Reality environments.