De-optimization dynamics with growing mismatch  (i.e., Free Energy) between the Executive Network and Default Mode Network. The Executive Network representing instant occurrences  and the Default Mode Network representing internal representations.   Thus optimization is the process of matching dynamics between internal representations and actual occurrences. De-optimization dynamics has the emergent property of depressed mood     
Imaging graphs of the Executive Network and Default Mode Network should be assessed over-time, and a free-energy delta distance (Humming distance like measure) evaluated. Reducing this measure will require increased plasticity More spines dendrite and neurons will enable increased brain plasticity with free energy reducing effect
Traditionally Serotonin Specific Reuptake Inhibitors (SSRI’s) are administrated also theoretically consider alternative (enhancing) neuronal-plasticity induction using cortical transcranial Magnetic Stimulation (TMS) transcranial Direct Current Stimulation tDCS, transcranial random Direct Current Stimulation trDCS. Additionally, consider Cognitive Behavioural Therapy like (CBT-like) personalized Virtual-Reality (VR) interventions. Use any intervention that will increase plasticity and reduce free energy.